12th Annual DDX3X Foundation Scientific Conference

12th Annual DDX3X Foundation Scientific Conference

October 22-24, 2026 in Wilmington, DE

Please join our community at The DDX3X Foundation's 12th Annual Scientific Conference taking place October 22-24, 2026 in Wilmington, DE at the Hotel DuPont.

The cost to attend the conference is $399/adult attendee and $149/child attendee. This includes a welcome reception and dinner on Thursday; breakfast, lunch, dinner, and snacks on Friday; and a family fun activity with refreshments on Saturday; as well as access to all conference sessions on Friday.

A room block is available at Hotel DuPont. Sleeping rooms are available 10/21-10/25. All attendees are responsible for booking and paying for their own lodging.

Hotel Du Pont (Conference hotel)
Room Rate: $279/night
Deadline for booking: September 14, 2026
Booking Link

Please find the 2025 agenda below. The 2026 agenda will be similar; however, exact topics, speakers, and timing is TBD.

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Thursday, October 22 
Registration + Family Meet & Greet 
3:00pm - 5:00pm

Welcome Event & Dinner 
6:00pm - 8:00pm | 

Friday, October 23 
Babysitting
8:00am - 5:00pm

Registration Open 
7:30am - 9:00am

Breakfast 
7:30am - 9:00am

Optional: Intro to DDX3X Q&A Session/Orientation 
8:00am – 8:50am
This optional discussion is perfect for new families and those who are interested in learning more about the Foundation and the basics of DDX3X. Questions are welcome. 

Welcome and Opening Remarks 
9:00am – 9:30am
This session will set the stage for the rest of the conference and include an overview of our patient population, the work the Foundation is doing to advance research, and the research that is currently being conducted.

Understanding the Larger Scientific Picture and FAQs
9:30am – 10:15am
This presentation will highlight how the Foundation’s scientific priorities advance the overarching goal of improving patients’ lives. It will also share key insights from the Research Roundtable, held the previous day for researchers and physicians.

Networking/Rest Time 
10:15am – 10:45am

Animal Models 
10:45am - 11:45am
This panel discussion will provide an overview of the work being done on DDX3X in animal models and will answer important basic questions including: Why do animal models matter? Why should families care about animal models? How do they help DDX3X patients?

Gene Therapy Fireside Chat
11:45am – 12:30pm
The Gray Lab will present on the work they have done on gene therapy for DDX3X and outline what is to come with the help of funding from the Foundation. This session will also explain what gene therapy is and why it is a promising therapeutic approach.

Lunch 
12:30pm – 1:30pm

Clinical Findings & Patient Interaction
1:30pm – 2:15pm
This panel will include a presentation of recent clinical observations of patients as well as a discussion among participants about the natural history study. 

Parent Panel 
2:15pm – 3:15pm
Hear about the lived experiences of parents of children of varying ages and abilities. The audience will have ample time to ask questions.

Networking/Rest Time
3:15pm – 3:45pm

Break Out Sessions
3:45pm – 4:45pm
Families will break into small groups based on areas of concern including communication, toilet training, sleep issues, Cyclical Vomiting Syndrome, puberty, and other common issues. These groups will be led by members of the Leadership Advisory Board. Additional details to follow.

Closing Remarks 
4:45pm
What are the next steps? How do you take what you’ve learned today and actively contribute to scientific advancement for DDX3X Syndrome?

Closing Dinner 
6:30pm – 8:30pm 

Saturday, October 24 
Family Fun Day at Buccini Farms 
10:00am - 2:00pm
217 Cossart Road Chadds Ford, PA 19317
Hayride at 10:30am!